創薬流通市場「薬市楽座」

安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。

創薬流通市場である薬市楽座では、弊社がお預かりしている創薬シーズ・技術の情報をリストアップしています。ご興味に応じて検索していただくことが可能です。また、リストのダウンロードも行っていただけます。ご興味のあるものがあれば、お問い合わせボタンをクリックしていただき、弊社へのコンタクトをお願いいたします。追加情報を開示させていただきます。

なお、2019年6月27日より、日本語ページにおける、創薬シーズ、創薬技術の各リスト表記が英語に変更になりました。ダウンロード用のPDF、エクセルファイルは英語ページよりダウンロードできる資料と同一ですので、予めご了承下さいませ。

創薬シーズ・創薬技術一覧(PDF) 疾患領域別 創薬シーズ一覧(PDF) 創薬シーズ・創薬技術一覧(Excel)

絞り込み検索

掲載日 シーズ番号 作用機序 適応症 投与経路 モダリティ 開発ステージ 備考
20/04/22 GEM171 ARNT regulation Fibrosis in kidney, heart and liver Oral / or gene therapy Small molecule or morpholinos Discovery – Preclinical No effective therapy for fibrosis is available yet. ARNT homodimerizartion attenuates fibrosis progression and induces regenerative cellular responses. Several mechanisms of action and potential drugs were identified, which show inhibition of ARNT degradation or activation of ARNT expression. PCT pattent application filed.
Discussions are available for Japanese companies and Chinese companies.
問合せ
20/04/22 GEM170 Improved PCR Diagnostic for detection of Para- tuberculosis in animals and potentially Crohn's disease in humans in vitro Others POC obtained in animals New and improved PCR diagnostic test for fast and early detection of Mycobacterium avium subspecies paratuberculosis (MAP). This method shows better performance than current ELISA as well as on current PCR tests. Diagnostic test for early MAP detection in domestic livestocks, exotic ruminations and human patients.
Discussions are available for Japanese companies and Chinese companies.
* Successfully tested in feces, blood, milk, sperm and tissue samples
問合せ
20/04/16 GEM-CVD02 Immune modulation (reduction of cytokine storm) with anti-viral medicine COVID-19 Oral Small molecule Launch COVID-19 progressing process is by first infecting from the virus and intriguing immune system modulated pro-inflammation, further proceeding to more serious inflammation, and later evolving to commencement of pro-fibrosis with infected pneumonia.TLR4 signaling pathway is closely associated with inflammation, immunity, and lung diseases. A TLR4 antagonist works well as an immune modulator for applications on pro-inflammatory diseases. GEM-CVD02 is a launched compound that has TLR4 antagonist activity and is expected the efficasy in combination of anti-viral medicine. GMP manufactured and FDA approved CTM capsules of this candidate are ready for clinical trial uses. 問合せ
20/04/10 GEM-CVD01 SARS-CoV-2 spike protein expression from RNA followed by antibody response COVID-19 Intra- muscular RNA Vaccine Preclinical This program is a rapid COVID-19 vaccine development. This vaccine is developed on the basis of established technologies of RNA delivery and nanostructured lipid carrier formulation. GEM-CVD01 rapidly induces robust immune responses. 問合せ
20/04/10 GEM168 Heat-killed mycobacterium vaccae Tuberculosis (TB) Oral Vaccine Phase 3 First-in-class tuberculosis immunotherapy to be used as an oral adjunct to standard TB drugs. In a 1-month phase 2 trial, the mycobacterial clearance in sputum smears was observed in 72% and 19% of patients on GEM168 and placebo, respectively. 問合せ
20/04/08 GEM167 Elimination of MADD protein Solid tumors i.v., intra-tumoral Gene therapy Preclinical A systemically deliverable oncolytic viral vector to target and eliminate the MADD protein overexpressed in a wide range of human cancer cell lines and involved in resistance. Systemic delivery demonstrated to colon, breast, liver, and ovarian tumors with no liver or kidney damage. Our parental vector infects and replicates only in cancer cells and has undergone extensive distribution and toxicity studies in mice and baboons and was previously approved for human trials. Breast, liver, and anaplastic thyroid cancer using siRNA achieved 41-60% TGI as mono or combo therapy. 問合せ
20/03/31 GEM166 Anti-Nodal antibody Melanoma, Breast cancer, Pancreatic cancer and Hepatocellular carcinoma i.v. Antibody Preclinical The first anti-Nodal antibody drug targeting cancer stem cells and aggressive tumors.
Nodal is a secreted protein in the embryo. The expression is lost in most adult tissues, but is reactivated in aggressive tumor cells. Expression level is highly correlated with invasion, metastasis, drug resistance and cancer prognosis.
Combination of anti-Nodal Ab with current therapies is more effective than monotherapy. A companion diagnostic Nodal ELISA kit is also being developed which can be used as a biomarker for patient selection and disease monitoring.
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20/03/25 GEM035 An anti-ENO1 antibody Immune diseases, various cancers s.c. Protein US FDA IND cleared GEM035 is a humanized antibody against unique ENO1 target. This therapeutic antibody is first-in-class to target inflammatory macrophage and demonstrates efficacy in animal models of MS, IPF, and IBD. It also showed efficacy in animal models of lung, pancreatic, and prostate cancer, most likely by targeting tumor associated macrophage (TAM). GEM035 may be developed for treatment of COVID-19 induced ARDS based on its capability to suppress macrophage related immune response. GEM035 has a worldwide patent protection. US IND of GEM035 is approved and active now for treating MS. 問合せ
20/03/11 GEM164 Anthracycline topoisomerase II inhibitor Breast cancer, Bladder cancer, Kaposi's sarcoma, lymphoma, and Acute lymphocytic leukemia i.v. Small molecule Bioequivalence study completed Generic pegylated liposomal doxorubicin hydrochloride. Doxorubicin is well known to cause cardiotoxicity and develop congestive heart failure. Cardiotoxicity of GEM164 is expected to be substantially lower than non-liposomal doxorubicin. Bioequivalence with CAELYX has been demonstrated.
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20/03/02 GEM163 Reduction of virus-replication and reduction of inflammation Virus diseases (incl. coronaviruses)** Oral Oligo-saccharides NDIN** ready A novel, intestinally absorbable derivative (pat. pend.) of GRAS αCD (α-cyclodextrin) to reduce virus entry (endocytosis) and replication/assembly of virueses (availability of lyso-phospholipids). βCDs have been effective in vitro against many virus infections, incl. coronaviruses, and topically against influenza and HSV2. αCDs avoid the ototoxicity of βCDs and were more effective (tested in HIV-1 cells).
**New dietary ingredient notification as a nutritional supplement/FSMP
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