|21/01/06||GEM238||CSN5 inhibitor||Cancer||i.v.||Peptide||Preclinical||- Identifying CDK2 binding regions within the CSN5 protein
- Specifically inhibits the binding between CSN5 and CDK2 in "small complex" that is specifically expressed in cancer cells.
- It is possible to specifically inhibit the growth of cancer cells while suppressing the effect on normal cells.
|21/01/04||GEM237||Autologous chondrocyte cell therapy for cartilage repair/regeneration||Chondral and osteochondral articular lesions of the knee||Arthro- scopic implan- tation||Cell and scaffold||Launch||The autologous cartilage repair system （a device kit consisting of a bioabsorbable highly porous scaffold and an enzyme for processing removed a small amount of cartilage） is for one-step surgery. It does not require an ex vivo cell expansion process. Hyaline cartilage is regenerated and long-term effectiveness is superior to the marrow stimulation procedure.
|20/12/25||GEM236||Nicotinamide phosphoribosyltransferase （NAMPT） inhibitor||Hematological （AML, ALL, lymphoma, MM） and some solid tumors （sarcoma, kidney, melanoma. etc）||Oral||Small molecule||Phase 1/2a||-NAMPT is critical for the growth/survival of hematological cancers.
-Synthetic small molecule structurally unrelated to NAMPT substrate or known inhibitors. -will be the First-In-Class drug.
-Favorable pharmacological and toxicological profiles, showed no ophthalmic toxicity.
-May increase susceptibility to other targeted cancer drugs (BCL-2, PARP, tyrosine kinase, proteasome, and HDAC inhibitors, anti-PD-1 antibodies) and DNA-damaging chemo/radiotherapy. Synergizes with tumor-specific mutations (IDH1/2, PPM1D, DNA repair deficiency).
-Phase I study, which is near completion, demonstrated favorable toxicology profile with myeloid cells dose-limiting toxicity and signs of efficacy seen in several patients.
|20/12/25||GEM235||Mineral sunscreen powder||Sunscreen||Topical||Natural ingredient||Commecial||GEM235 is an easy-to-use brush applicator, filled with an effective mineral powder with SPF 50. The 100% natural formula makes GEM235 safe to use on rash-prone skin, eczema, allergy-prone skin and sensitive skin.||問合せ|
|20/12/21||GEM234||Crosstalk of TGF-β signal and Wnt/β-catenin signal||Liver fibrosis, Nonalcoholic steatohepatitis, Kidney fibrosis, Renal fibrosis, Liver cancer, COVID-19||Injection||Small molecule||Preclinical||GEM234 is a novel small molecular which has suppressive effects on both hepatic stellate cell activation and kidney and liver fibrosis by suppressing TGF-β/Smad pathway via inhibition effect of Wnt/β-catenin pathway. GEM234 shows a higher suppressive effect on liver cancer stem cells than 5-FU. Wnt/β catenin inhibitors can block the infection of SARS-Cov-2, and GEM234 has potential to prevent occurrence of ARDS and cardiovascular damage in COVID-19.||問合せ|
|20/12/21||GEM062||Anandamide（AEA）-releasing topical formulation （sustained release for about 24 hours）||Cutaneous Lupus, （and other autoimmune/ inflammatory skin conditions）||Topical||Small molecule
||Preclinical||Tissue imaging to demonstrate efficient penetration and controlled release of AEA from
AEA-loaded GEM062. Efficacy of AEA-loaded GEM062 in treating
cutaneous lesions in murine model of CLE has been demonstrated.
|20/12/21||GEM092||Androgen receptor agonist||Hypogonadism||Oral （BID）||Small molecule
||Received FDA tentative approval||A novel oral prodrug of testosterone that is designed to help restore normal testosterone levels in hypogonadal men. GEM092 was well tolerated and met the primary end-points in Phase 3 testing with twice daily dosing. Easy to use for patients and physicians to prescribe due to fixed doing regimen.||問合せ|
|20/12/04||GEM233||Inhibition of pro-cytokines, enhancement of growth factor PDGF||Diabetic foot and leg ulcers||Topical||Botanical||Phase 2 completed||-Small molecules from soybean extract.
-MOA facilitates multiple phases at molecular levels of wound healing processes.
-Effective in STZ induced diabetic wound model and cell migration quality control.
-In Phase 2 study, ulcer complete closure rate up to 12 weeks is 32.7% in GEM233 group vs 15.4% in placebo group. Subjects in the GEM233 group had an average of 73±2.9 days to achieve ≥ 90% reduction in target ulcer size.
|20/11/27||GEM232||Anti-soluble MICA/MICB antibody||Prostate Cancers （mCRPC）, other cancers||i.v.||Antibody
||Preclinical||- GEM232 is a humanized antibody specific for soluble NKG2D ligands MICA and MICB, which are multi-mechanistic suppressors of the immune system that become upregulated in cancer but are normally absent.
- GEM232 binds non-membrane bound MICA/B (shed/soluble forms) but not cell surface attached versions, thereby offering safety benefits such as avoiding autoimmunity.
- Antibody binding may help prevent immunosuppression and may enhance NK and CD8+ T cell activation mediated by the NKG2D receptor leading to tumor cell killing. Both arms of immune system (innate and adaptive) can be impacted.
- Significant tumor inhibition demonstrated using prostate xenografts in both immune compromised mice and in mice with humanized immune systems (hPBMC), with no observable toxicity. A unique epitope has been identified for this high affinity antibody.
|20/11/25||GEM231||JNK inhibitor||Dry Eye, Dry and Wet AMD, Uveitis, Chronic inflammation alternative to Steroids||Intra- vitreal, Subcon- junctival, Drops||Peptide
||Clinical Phase 3 （performed in acute post surgery）||・Potent and selective non-ATP competitive hJNK2 and hJNK3 inhibitor
・Full D amino acids – TAT peptide with high resistance to proteases and highly soluble in saline
・Coupled to a carrier sequence that selectively delivers it into the cell
・Excellent safety and toxicology profile (therapeutic indexes in 100 -1000 range)
・Administered to 1000+ patients to date with no sign of intolerance
・Excellent patent position
・Simple to manufacture at low COG per dose