創薬流通市場「薬市楽座」

安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。

創薬流通市場である薬市楽座では、弊社がお預かりしている創薬シーズ・技術の情報をリストアップしています。ご興味に応じて検索していただくことが可能です。また、リストのダウンロードも行っていただけます。ご興味のあるものがあれば、お問い合わせボタンをクリックしていただき、弊社へのコンタクトをお願いいたします。追加情報を開示させていただきます。

なお、2019年6月27日より、日本語ページにおける、創薬シーズ、創薬技術の各リスト表記が英語に変更になりました。ダウンロード用のPDF、エクセルファイルは英語ページよりダウンロードできる資料と同一ですので、予めご了承下さいませ。

創薬シーズ・創薬技術一覧(PDF) 疾患領域別 創薬シーズ一覧(PDF) 創薬シーズ・創薬技術一覧(Excel)

絞り込み検索

掲載日 シーズ番号 作用機序 適応症 投与経路 モダリティ 開発ステージ 備考
21/01/06 GEM238 CSN5 inhibitor Cancer i.v. Peptide Preclinical - Identifying CDK2 binding regions within the CSN5 protein
- Specifically inhibits the binding between CSN5 and CDK2 in "small complex" that is specifically expressed in cancer cells.
- It is possible to specifically inhibit the growth of cancer cells while suppressing the effect on normal cells.
問合せ
21/01/04 GEM237 Autologous chondrocyte cell therapy for cartilage repair/regeneration Chondral and osteochondral articular lesions of the knee Arthro- scopic implan- tation Cell and scaffold Launch The autologous cartilage repair system (a device kit consisting of a bioabsorbable highly porous scaffold and an enzyme for processing removed a small amount of cartilage) is for one-step surgery. It does not require an ex vivo cell expansion process. Hyaline cartilage is regenerated and long-term effectiveness is superior to the marrow stimulation procedure.
問合せ
20/12/25 GEM236 Nicotinamide phosphoribosyltransferase (NAMPT) inhibitor Hematological (AML, ALL, lymphoma, MM) and some solid tumors (sarcoma, kidney, melanoma. etc) Oral Small molecule Phase 1/2a -NAMPT is critical for the growth/survival of hematological cancers.
-Synthetic small molecule structurally unrelated to NAMPT substrate or known inhibitors. -will be the First-In-Class drug.
-Favorable pharmacological and toxicological profiles, showed no ophthalmic toxicity.
-May increase susceptibility to other targeted cancer drugs (BCL-2, PARP, tyrosine kinase, proteasome, and HDAC inhibitors, anti-PD-1 antibodies) and DNA-damaging chemo/radiotherapy. Synergizes with tumor-specific mutations (IDH1/2, PPM1D, DNA repair deficiency).
-Phase I study, which is near completion, demonstrated favorable toxicology profile with myeloid cells dose-limiting toxicity and signs of efficacy seen in several patients.
問合せ
20/12/25 GEM235 Mineral sunscreen powder Sunscreen Topical Natural ingredient Commecial GEM235 is an easy-to-use brush applicator, filled with an effective mineral powder with SPF 50. The 100% natural formula makes GEM235 safe to use on rash-prone skin, eczema, allergy-prone skin and sensitive skin. 問合せ
20/12/21 GEM234 Crosstalk of TGF-β signal and Wnt/β-catenin signal Liver fibrosis, Nonalcoholic steatohepatitis, Kidney fibrosis, Renal fibrosis, Liver cancer, COVID-19 Injection Small molecule Preclinical GEM234 is a novel small molecular which has suppressive effects on both hepatic stellate cell activation and kidney and liver fibrosis by suppressing TGF-β/Smad pathway via inhibition effect of Wnt/β-catenin pathway. GEM234 shows a higher suppressive effect on liver cancer stem cells than 5-FU. Wnt/β catenin inhibitors can block the infection of SARS-Cov-2, and GEM234 has potential to prevent occurrence of ARDS and cardiovascular damage in COVID-19. 問合せ
20/12/21 GEM062 Anandamide(AEA)-releasing topical formulation (sustained release for about 24 hours) Cutaneous Lupus, (and other autoimmune/ inflammatory skin conditions) Topical Small molecule
Preclinical Tissue imaging to demonstrate efficient penetration and controlled release of AEA from
AEA-loaded GEM062. Efficacy of AEA-loaded GEM062 in treating
cutaneous lesions in murine model of CLE has been demonstrated.
問合せ
20/12/21 GEM092 Androgen receptor agonist Hypogonadism Oral (BID) Small molecule
Received FDA tentative approval A novel oral prodrug of testosterone that is designed to help restore normal testosterone levels in hypogonadal men. GEM092 was well tolerated and met the primary end-points in Phase 3 testing with twice daily dosing. Easy to use for patients and physicians to prescribe due to fixed doing regimen. 問合せ
20/12/04 GEM233 Inhibition of pro-cytokines, enhancement of growth factor PDGF Diabetic foot and leg ulcers Topical Botanical Phase 2 completed -Small molecules from soybean extract.
-MOA facilitates multiple phases at molecular levels of wound healing processes.
-Effective in STZ induced diabetic wound model and cell migration quality control.
-In Phase 2 study, ulcer complete closure rate up to 12 weeks is 32.7% in GEM233 group vs 15.4% in placebo group. Subjects in the GEM233 group had an average of 73±2.9 days to achieve ≥ 90% reduction in target ulcer size.
問合せ
20/11/27 GEM232 Anti-soluble MICA/MICB antibody Prostate Cancers (mCRPC), other cancers i.v. Antibody
Preclinical - GEM232 is a humanized antibody specific for soluble NKG2D ligands MICA and MICB, which are multi-mechanistic suppressors of the immune system that become upregulated in cancer but are normally absent.
- GEM232 binds non-membrane bound MICA/B (shed/soluble forms) but not cell surface attached versions, thereby offering safety benefits such as avoiding autoimmunity.
- Antibody binding may help prevent immunosuppression and may enhance NK and CD8+ T cell activation mediated by the NKG2D receptor leading to tumor cell killing. Both arms of immune system (innate and adaptive) can be impacted.
- Significant tumor inhibition demonstrated using prostate xenografts in both immune compromised mice and in mice with humanized immune systems (hPBMC), with no observable toxicity. A unique epitope has been identified for this high affinity antibody.
問合せ
20/11/25 GEM231 JNK inhibitor Dry Eye, Dry and Wet AMD, Uveitis, Chronic inflammation alternative to Steroids Intra-  vitreal, Subcon-  junctival, Drops Peptide
Clinical Phase 3 (performed in  acute post surgery) ・Potent and selective non-ATP competitive hJNK2 and hJNK3 inhibitor
・Full D amino acids – TAT peptide with high resistance to proteases and highly soluble in saline
・Coupled to a carrier sequence that selectively delivers it into the cell
・Excellent safety and toxicology profile (therapeutic indexes in 100 -1000 range)
・Administered to 1000+ patients to date with no sign of intolerance
・Excellent patent position
・Simple to manufacture at low COG per dose
問合せ