Drug Candidate Marketplace

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Date Candidate Mechanism of action Indication Route Development stage Note
07/26/18 GEM030 PI3K δ/γ dual inhibitor Hematological malignancies, T cell Lymphoma, Hodgkin Lymphoma Oral Phase 2 - Highly specific dual PI3K δ/γ inhibitor with nano‐molar inhibitory potency
- Single-agent and combination with immune checkpoint inhibitor programs
- Inhibits primary patient leukemic/lymphoma cells
- Dose escalation study demonstrated an acceptable safety and tolerability with promising clinical activity
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07/20/18 GEM029 A cancer stem cell-associated transcription factor inhibitor Malignant gliomas including glioblastoma (GBM) Oral Phase 1 ready -Directly kills the cancer stem cells.
-Significantly improves survival in orthotopic GBM PDX models.
-Inhibits tumor growth in a mouse implanted with GBM cells and the growth inhibition is augmented by combination with temozolomide/radiation.
-No significant toxicities are identified at therapeutic doses.
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07/09/18 GEM028 miRNA targeting refractory colon cancer with mutated K-ras and refractory pancreatic cancer pancreatic cancer colon cancer IV Preclinical The miRNA regulates K-ras, Bcl2, survivin, and NF-kB and demonstrate excellent antitumor effect in vitro and in vivo. Contact
07/09/18 GEM027 miRNA targeting refractory colon cancer with mutated K-ras colon cancer IV Preclinical The miRNA regulates EGFR signaling pathway by directly inhibiting of both KRAS and AKT1 and demonstrate excellent antitumor effect in vitro and in vivo. Contact
07/09/18 GEM026 siRNA suppressing the expression of novel cancer stem cell gene "Gene A" Cancer IV Preclinical -Novel cancer stem cell gene "Gene A", which was discovered by single cell analysis of cancer stem cell, shows character as follows.
1.Superior cancer stem cell diagnostic marker than known cancer stem cell marker CD44v9
2.SiRNA targeting Gene A demonstrate excellent antitumor effect with currnet medicines.
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07/09/18 GEM025 miRNA suppressing the expression of a protein characteristic of pancreatic cancer stem cells pancreatic cancer IV Preclinical Excellent antitumor effect was demonstrated in uniquely established pancreatic cancer stem cell model in vitro and in vivo. Contact
07/09/18 GEM024 Selective inducer of apoptosis through modulation of NF-kB Oral Squamous Cell Carcinoma Phase 2 ready (FDA approved IND) -First-in-class, combination therapeutic that simultaneously upregulates a cluster of genes promoting cell death and downregulates a cluster of genes promoting survival of cancer cells.
-Phase 1 in USA results showed no significant AE and dose-dependent modulation of key biomarkers involved in disease pathogenesis.

Route : Oral, pastille based topical delivery
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07/05/18 GEM023 Synthetic miniprotein for influenza virus Infuenza Preclinical Computationally designed miniprotein with demonstrated pre and post-exposure efficacy against the disease.
-Neutralizes multiple variants like H1N1 and H5N1 better than today’s standard of care while keeping immunogenicity low enough to allow chronic treatments.

Route : Inhaled
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07/05/18 GEM022 Computational drug design platform for synthetic miniproteins asthma, flu and neuropathic pain etc. Discovery -High-value, high-complexity protein design by computational and high-throughput techniques.
-Mimics proven monoclonal antibodies with safer, more effective biologic alternatives.
-Designed to a specific drug target epitope with sub-nM affinity.

Route : Inhaled, Oral, Topical, IV
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07/05/18 GEM021 Opioid and non-opioid analgesics with respiratory stimulant Pain Oral Preclinical (close to IND) -Combination of generic opioid/non-opioid analgesics with a generic respiratory stimulant using a regulatory approach known as the 505(b)2 submission.
-First drug introduction therapeutically equivalent to Vicodin® that prevents overdose death, deters abuse and prevents addiction.
-Low cost of goods.
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