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Date Candidate Mechanism of action Indication Route Development stage Note
10/25/18 GEM047 Lactoferrin complexes Pain on Peripheral Neuropathy, Cancer IV Preclinical Improved PK profile over natural lactoferrin.
Analgesic effect on periferal neuropathy induced by oxaliplatin.
Inhibitory effects on the growth of syngeneic murine lung cancer model
Inhibitory effects on the growth of human non-small cell lung cancer cell in vitro.
Positive effect of treatment on sepsis mice model.
10/25/18 GEM046 Indirect activator of AMPK Hyper- lipidemia, type 2 diabetes, cancer Oral Preclinical Derivative of fungus product ascochlorin.
Good PK profile in rats.
Superior effects than metformin on blood glucose and triglyceride level in diabetic mice model.
Significant enhancement of the efficacy in combination with metformin on T2D model
Significant enhancement of the antitumor activity of anti-PD-1 antibody in mouse model
09/20/18 GEM045 Autotaxin Inhibitor NASH, Panacreatic cancer Oral Preclinical Showed antifibrotic efficacy with significant histopathological score reductions in chronic pancreatitis and NASH (Stelic STAM & MCD) in mice.
Showed significant anti-inflammatory effects in paw edema animal study.
09/20/18 GEM044 TLR4-NOX dual inhibitor AIH, Pancreatic cancer and IBD Oral Preclinical 5-10 times more potent on NOX activity than GKT-137831.
Hepatoprotection with significant reductions on ALT/AST in AIH in mice.
Showed antifibrotic efficacy with significant histopathological score reductions in caerulein-induced pancreatic fibrosis in mice.
Showed antifibrotic efficacy with significant NAS reductions in Stelic-STAM (NASH) in mice.
09/20/18 GEM042 TLR4 antagonist NAFLD, AIH, CLD and CD Oral Phase 2 NAFLD (nonalcoholic fatty liver disease): The phase 2 results demonstrated significant improvement on relevant diagnosis and biomarkers.
AIH (autoimmune hepatitis; orphan designation): The phase 2 (open label) results will be available soon.
CLD(chronic liver disease by HCV infection): A strong trend of improvement of liver function and safety in Phase 2.
CD (Crohn's disease): Good efficacy in three Phase 2 POC studies.
The drug is safe and tolerable in these trials.
09/20/18 GEM041 Dual inhibitor of catechol-O-methyltransferase and dopa decarboxylase Parkinson's disease Oral Preclinical First dual inhibitor in the World.
Almost same inhibitory activities for the two enzymes.
The enzyme activities were inhibited strongly in the liver, but not in the brain.
08/31/18 GEM040 Topical anti-inflammatory Joint pain, Muscle pain, Gout, Local inflammatory pain see Note Preclinical Topical formulations of Ibuprofen, Naproxen, Diclofenac to use in the treatment of inflamatory pain and related conditions
Formulation shows 5 to 10X increase human skin permeation coupled
Potential for OTC or RX introduction: minimal development timeline

08/31/18 GEM039 Antifungal Onychomy- cosis see Note Preclinical Novel and unique topical formulation of Terbenafine with exceptional permeation (40 fold) across the human nail.
Potential for OTC or RX introduction: minimal development timeline

08/31/18 GEM038 Locally acting anti-inflammatory- Trigeminal neuro-inflammation Migraine Phase 2a Clinical POC in acute migraine therapy in Phase 2a
Efficacy comparable to Triptans but with no systemic side effects or restrictions
Shortened development timelines (NDA:2021)
Product opportunity for use in Temporomandibular Joint Disease and trigeminal neuralgias
08/31/18 GEM037 Allosteric modulator of the CCR3 receptor Asthma, rhinitis Oral Phase 2a In phase 2a:
Highly significant effects on the methacholine provocative response
Showed trends to improvement in EAR (Early Phase Allergic Response)
Reduced induced sputum eosinophil percentage and increased percent blood eosinophil