|20/07/08||GEM198||A fixed dose combination of melatonin and resveratrol||Alopecia / Hair Loss||Topical||Small molecule||Pre registration||Resveratrol stimulates hair growth by decreasing prostaglandin D2 (PGD2) and increasing prostaglandin E2 (PGE2). Melatonin is a neurohormone involved in multiple physiological processes underlying circadian rhythm. Due to its antioxidant properties, melatonin has remarkable protective effects on cells and anti-apoptotic properties. Hence the association between melatonin and hair growth. The effect of melatonin on hair growth may be moderated by an interaction with androgens and estrogens and their receptors. Results from a clinical study demonstrated that GEM198 was more effective at stopping hair loss than Minoxidil. US patent issued, and international patents have been filed.||問合せ|
|20/07/08||GEM197||A fixed dose combination of minoxidil, finasteride and latanoprost||Androgenetic alopecia||Topical||Small molecule||Phase 3||Minoxidil is a potassium channel blocker that prevents hair loss by improving blood flow to the hair follicle. It also suppresses androgen receptor function and stimulates the production of prostaglandins. Finasteride is a 5 alpha reductase inhibitor that reduces the conversion of testosterone to dihydrotestosterone (DHT), which in turn reduces the binding of DHT to the androgen receptor, thereby reducing the miniaturization of the hair follicle. Finasteride also upregulates SULT1A1, which activates the pro-drug of minoxidil into its active form - minoxidil sulfate Latanoprost is a prostaglandin analogue that has a positive stimulatory effect on the hair follicle and induces the conversion from telogen to anagen phase in the hair growth cycle. Results from a completed phase 2 study have demonstrated that GEM197 is a well-tolerated, once a day, topical fixed dose triple combination therapy that stimulates new hair growth and prevents further hair loss for the treatment of androgenetic alopecia in men 24-65 years old. The FDA has given a roadmap to start a Phase 3 clinical trial under 505(b)(2). International patents have been issued.||問合せ|
|20/06/26||GEM196||Potassium-Competitive Acid Blocker (P-CAB)||Peptic ulcer||Oral||Small molecule||Phase 2 completed||Phase 3 is ongoing.P-CABs are the best treatment with better and fater efficay for gastric acid-related gastrointestinal diseases such as gastric and duodenal ulcer, GERD, NERD, ZES and etc.
GEM196 is a potentially best-in-class P-CAB
- Faster clinical benefit in phase 2 study compared with Lansoprazole for duodenal ulcer treatment.
- Rapid and high absorption, oral bioavailability in clinical study.
- Lower toxicity and better PK, PD than TAK-438.
- Acid stability- exempt acid protection
- Longer lasting-higher concentration on target site
- Less individual differences- isoenzyme CYP2C19 metabolism tiny dependence.
|20/06/18||GEM-CDV06||A potent DNA-immunotherapy against SARS-CoV-2||COVID-19||Intra- venous Injection||In vivo CAR-T||Preclinical||DNA vector with Anti-CoV-2 Receptors inserted into our original platform (TGEM052) and delivered through liposomes into lymph nodes. The plasmid moves into the nucleus of normal T-cells and converted to CAR.
Anti-CoV-2 CAR T-cells attack the virus and diseased cells and destroy them.
|20/06/18||GEM195||A potent DNA-immunotherapy for MAGE A||Triple Negative Breast Cancer （TNBC）||Intra- muscular Injection||DNA Plasmid||Preclinical||DNA vector with MAGE A inserted into our original platform (TGEM052) and delivered into muscle cells using intramuscular injections followed by electroporation. The plasmid moves into nucleus of muscle cells and starts to over-express MAGE A, eliciting an immune response that can target MAGE A on cancer cells and destroy them||問合せ|
|20/06/18||GEM194||PDE4 inhibitor||Autoimmune dermal disorders （bullous pemphigoid, psoriatic arthritis）||Oral||Small molecule||Phase 1||GEM194 is the best-in-class PDE4 inhibitor having potentially a wider therapeutic index compared to clinically efficacious and marketed PDE4 inhibitors such as apremilast and roflumilast. Bullous pemphigoid (BP) is chronic autoimmune skin disorder resulting in generalized, pruritic, bullous lesions in elderly patients currently treated with corticosteroids and multiple antibacterial agents. Anti-inflammatory profile of PDE4 inhibition associated with multiple immune- and inflammatory cells is anticipated to taper doses of systemic corticosteroid. Opportunities exist to extend clinical development for other inflammatory dermal indications such as psoriatic arthritis.||問合せ|
|20/06/18||GEM193||PDE4 inhibitor||NASH||Oral||Small molecule||Phase 1||GEM193 was efficacious in reducing plasma ALT levels, hepatic fibrosis area, TG levels in an animal model of NASH. In addition, GEM193 exhibited anti-obesity and anti-diabetic properties in vivo. PDE4 enzyme is expressed not only in disease-relevant cell population, but also in ubiquitously whole body and its inhibition results in anti-inflammatory, anti-fibrotic and anti-metabolic effects that fit favorable profile as a monotherapy for NASH.||問合せ|
|20/06/18||GEM191||Potentiation of detrusor contraction||Underactive bladde||Oral||Small molecule||Phase 1||Detrusor underactivity is a main cause of underactive bladder, which causes multiple lower urinary tract symptoms such as residual urine and urinary tract infection. GEM191 potentiates detrusor contraction and shows no impact on bladder storage function or urethral function. Stratified analysis clearly indicates efficacy to reduce residual urine in patients with detrusor underactivity.||問合せ|
|20/06/15||GEM190||Lipase inhibition, α-amylase inhibition, aldehyde dehydrogenase (ALDH) activation and anti-oxidant capacity increase||Overweight and obesity Alcohol and tobacco smoke toxicity||Oral||Natural product||Clinical||GEM190 is a combination of two purified plant extracts in a form of oral liquid food supplement developed for appetite and weight control. Also, it reduces alcohol and tobacco smoke toxicity by activation of aldehyde dehydrogenase (ALDH) and increasing anti-oxidant capacity. In overweight and obese patients, GEM190 showed significant suppression of appetite and reduction of body weight and body fat as well as it had a beneficial effect on fluid distribution during weight loss, as observed in 12-week treatment. Increased ALDH activity in PBMC was observed already after 24 hours after initiation of GEM190 administration. GEM190 may provide a salvage solution in populations known to be particularly susceptible to a build-up of excess acetaldehyde, such as having a ALDH2*2 genetic mutation. GEM190 claims are under two PCT applications.||問合せ|
|20/06/05||GEM-CVD05||Immune-modulate and slow down the hyperactive active immune system from attacking lung cells (and other solid organs)||Prevention of Respiratory Falure by Treating Acute Respiratory Disease Syndrome Resulting from COVID-19 and other viral pandemics||Refer to Note*||Protein**||Phase 3 ready***||1. Treatment of blood/MSCs, Tregs, NK cells with GEM-CVD05 to improve their homing to patients’ lungs, thereby enabling those cells to slow down the hyperactive immune attack on the lungs to help prevent deaths from respiratory failure.
2. Treatment of cells such as stem cells enabling them to home/engraft more effectively to the bone marrow and accelerating immune reconstitution with ‘younger’ immune cells for improved viral infected cell killing.
*Infusion with blood, or MSCs, Tregs, NK cells to improve efficacy, safety and cost of care outcomes
**Used to treat MSCs, Blood, Tregs, NK cells , Stem Cells to Prevent deaths from respiratory failure
***Phase 2 study for other indication has been completed.