創薬流通市場「薬市楽座」
安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。
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| 掲載日 | シーズ番号 | 作用機序 | 適応症 | 投与経路 | モダリティ | 開発ステージ | 備考 | |
|---|---|---|---|---|---|---|---|---|
| 18/12/27 | GEM059 | Recombinant Human Interleukin-1 Receptor Antagonist | Please refer to Note | IM | Protein |
Phase 1 | Indication: 1: Infection, as manifested by febrile neutropenia, in patients with malignancies receiving chemotherapy drugs. 2: Diarrhea in patients with malignancies receiving chemotherapy drugs. 3. Gout arthritis Note: The world's first multiorgan protection agent for tumor chemotherapy. Inhibits cell cycle progression of normal cells and renders them resistanace to chemotherapy. No effects on tumor growth and their sensitivity to chemotherapy Phase 1 : No dose limiting toxicity, None of subjects presented grade 3 or above chemotherapy-induced neutropenia or diarrhea. Gout arthritis: Well tolerated and safe for patients who are restricted from NSAID, glucocorticoid, or colchicine. |
問合せ |
| 18/12/27 | GEM058 | Increase cellular ATP and promote wound healing | Diabetes foot ulcer | Topical | Small molecule |
Phase 2 | Reducing inflammation of endothelial cells of blood vessels. Increasing cellular ATP and speeding up the healing of wounds by promoting the migration of epithelia cells in the skin of wounds. The arrangement of actin which is essential for cell migration is ATP dependent. Applicable to all kind of wound and low cost treatment Phase 2: The estimated complete closure rate is around 60% (vs placebo 30%) |
問合せ |
| 18/12/27 | GEM057 | Increase hair follicle ATP and delay senescence of dermal papilla cells | Alopecia | Topical | Small molecule |
Phase 2 | Boosts the ATP of human follicle dermal papilla cells, thereby slowing down the aging speed and prolonging hair cycle. No side effects and shorter time to observe efficacy Human trial (Androgenetic Alopecia): significantly improved 37.5% vs 0% (placebo) during 2 months Phase 2 (Female pattern hair loss) : ongoing (comparison with minoxidil) |
問合せ |
| 18/12/13 | GEM054 | Intracellular superoxide removing agent | Please refer to Note | IV | Small molecule |
Phase 2 | Indication: Chemotherapy induced Peripheral Neuropathy (CIPN) Note: There is currently no approved drug to prevent or treat CIPN. Completion of Phase 2b study. Global Phase 3 started in US, Currently in preparation for Phase 3 in Japan, South Korea, Taiwan and Hong Kong. Can be licensed to Japan, South Korea, Taiwan and Hong Kong. |
問合せ |
| 18/12/13 | GEM053 | Substance for covering oral lesions (no active ingredients: medical device) | Control and relief pain of oral mucositis by chemotherapy/ radiotherapy | Local | Small molecule |
Launch | There is no standard treatment for chemo/radiotherapy induced mucositis–high unmet medical needs. Forms a mucoadhesive barrier film when applied in the oral cavity. Excellent control of oral pain (rapid and long-lasting effects and ready to use) Can be licensed to Korea. |
問合せ |
| 18/12/13 | GEM052 | Mitochondria-targeted apoptosis inducer | Please refer to Note | IV | Small molecule |
Phase 2 | Indication: Relapsed/Refractory Peripheral T-cell Lymphoma (PTCL) and other hematological cancers Note: No approved drugs for PTCL indication in Europe (3 drugs have been approved in Japan and US). Less toxic compared with competitors approved in Japan and US. US Phase 2a: 5 responders in 11 refractory PTCL and DLBCL patients, and 2 responders in 7 PTCL patients. Applicable to relapsed and refractory PTCL. Phase 2 Pan-Asia pivotal study is ongoing. Can be licensed to US/EU and China (except Beijing, Shanghai, and Guangzhou). |
問合せ |
| 18/12/10 | GEM051 | Protective agents from heat stress | Heatstroke | Oral | Other |
Preclinical | Suppression of vascular endothelial cell damage and production and release of inflammatory cytokines from blood cells due to heat stress. Ingredients derived from citrus fruit extract. |
問合せ |
| 18/11/22 | GEM050 | Curcumin analogue | CML, Pancreatic cancer, glioblastoma etc. | Oral | Small molecule |
Preclinical | Inhibited proliferation of CML and pancreatic cancer cells at the submicromolar level. Unlike imatinib, the inhibitory action is irreversible. Suppressed almost completely human CML cell growth without significant changes in body weight and peripheral white blood cell count in vivo. An incease in ROS/RCS produced by inhibition of their scavenging enzymes is assumed to be involved in anti-tumor action. Induced M phase arrest. |
問合せ |
| 18/11/15 | GEM049 | Pan-NOX inhibitor | IBD, IPF, Neurodegenerative diseases | Oral | Small molecule |
Preclinical | Highly potent NOX inhibitor : 20~50 times more potent than GKT-137831 Significant effects in DNBS-ulcerative colitis and LPS-induced acute inflammatory animal studies. Also showed positive results in IPF animal model. High oral bioavailability and clean off-targets profile. |
問合せ |
| 18/10/25 | GEM047 | Lactoferrin complexes | Pain on Peripheral Neuropathy, Cancer | IV | Protein |
Preclinical | Improved PK profile over natural lactoferrin. Analgesic effect on periferal neuropathy induced by oxaliplatin. Inhibitory effects on the growth of syngeneic murine lung cancer model Inhibitory effects on the growth of human non-small cell lung cancer cell in vitro. Positive effect of treatment on sepsis mice model. |
問合せ |