創薬流通市場「薬市楽座」
安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。
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| 掲載日 | シーズ番号 | 作用機序 | 適応症 | 投与経路 | モダリティ | 開発ステージ | 備考 | |
|---|---|---|---|---|---|---|---|---|
| 19/08/13 | GEM098 | GnRH receptor antagonist | Endometriosis and Uterine fibroids | Oral | Small molecule |
Phase 1 | In Phase 1b, GEM098 showed dose-dependent suppression of LH, FSH and E2. The suppressive effects on E2 lasted up to 24 hrs and were more excellent when compared with the published phase 1 data of Elagolix in healthy premenopausal women. No serious adverse events were seen and well tolerated up to 320 mg QD. | 問合せ |
| 19/08/13 | GEM097 | Factor VIIa derivative | Bypassing therapy in hemophilia with inhibitors | i.v. | Protein |
IND ready | GEM097 is rFVIIa fused to transferrin and has longer half-lives than rFVIIa in rats and monkeys. A cleavable linker between rFVIIa and trasferrin of GEM097 allows minimal reducuction of FVIIa activity due to fusion. Preclinical (GLP) toxicity studies did not show any toxic evidence in rats or monkeys. | 問合せ |
| 19/07/31 | GEM096 | Progesterone receptor agonist | Recurrent preterm birth | Oral | Small molecule |
Phase 2 completed | Potentially the first oral hydroxyprogesterone caproate product candidate indicated for the prevention of recurrent preterm birth and has been granted orphan drug designation by the FDA. An end of Phase 2 meeting was completed with the FDA. |
問合せ |
| 19/07/31 | GEM095 | Androgen receptor agonist | NASH, Cirrhosis | Oral | Small molecule |
Phase 1 | An oral prodrug of bioidentical testosterone that is being developed as a treatment of cirrhotic non-alcoholic steatohepatitis (NASH). | 問合せ |
| 19/07/31 | GEM094 | Androgen receptor agonist | NASH, Pre-Cirrhosis | Oral | Small molecule |
Phase 2 ongoing | An oral prodrug of bioidentical testosterone that is being developed as a treatment of non-alcoholic steatohepatitis (NASH) and is being studied in the LifT Phase 2 clinical study in biopsy confirmed NASH subjects. | 問合せ |
| 19/07/31 | GEM093 | Androgen receptor agonist | Hypogonadism | Refer to Note | Small molecule |
Phase 2 completed | Route: Oral (QD) A novel next generation oral prodrug of testosterone with potential for once-daily oral dosing that has completed Phase 2 testing. |
問合せ |
| 19/07/31 | GEM092 | Androgen receptor agonist | Hypogonadism | Refer to Note | Small molecule |
Refer to Note | Route: Oral (BID) Development stage: Phase 3 (a few months before PDUFA date) A novel oral prodrug of testosterone that is designed to help restore normal testosterone levels in hypogonadal men. GEM092 was well tolerated and met the primary end-points in Phase 3 testing with twice daily dosing. Easy to use for patients and physicians to prescribe due to fixed doing regimen. |
問合せ |
| 19/07/16 | GEM091 | Prevention of protein aggregation via increased intracellular ATP and increase of expression of tyrosine hydroxylase (TH) | Parkinson's disease | Oral/ nasal | Small molecule |
Preclinical | New treatment for Parkinson's disease. GEM091 increases intracellular ATP level and ATP is reported to boost protein solubility. GEM091 increases TH expression and dopamine production, reverses paraquat induced PD symptoms and improves behavior of 6-OHDA treated mice. | 問合せ |
| 19/07/16 | GEM090 | Increase cellular ATP and promote wound healing | Refer to Note | Topical | Small molecule |
Preclinical | Indication: Epidermolysis Bullosa (EB) Increasing cellular ATP and speeding up the healing of wounds by promoting the migration of epithelia cells in the skin of wounds. Expected to shorten wound healing time and improve EB patients' QOL with a formulation optimized for EB treatment. Moreover, maybe reduces the risk of squamous cell carcinoma which is highly related to Dystrophic EB patients. |
問合せ |
| 19/07/12 | GEM089 | Inhibition of pro-cytokines, enhancement of growth factor PDGF | Alzheimer's disease and vascular dementia | Topical | Botanical |
Phase 2 | Small molecules from soybean extract. MOA is different from Tau and Amyloid mechanisms. Effective in AlCl3 induced Alzheimer-like dementia model and bilateral common carotid artery occlusion induced vascular dementia model. In Phase 2 study, MMSE and ADAS-Cog for patients without any dementia medication indicated that 70-85% patients improved at weeks 4 and 12. |
問合せ |