創薬流通市場「薬市楽座」
安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。
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| 掲載日 | シーズ番号 | 作用機序 | 適応症 | 投与経路 | モダリティ | 開発ステージ | 備考 | |
|---|---|---|---|---|---|---|---|---|
| 19/05/30 | GEM073 | Kinase inhibitor of TGFβ-mediated phospho-SMAD2 signal transduction | COPD, IPF, Lung cancer | Oral | Small molecule |
Phase I ongoing | This kinase is selectively expressed in resident macrophages and airways epithelia of the lung and upregulated in COPD and IPF patients. A highly selective inhibitor showed efficacy across at least 3 different animal models relevant to COPD, IPF and NSCLC. |
問合せ |
| 19/05/30 | GEM072 | Orally available somatostatin analogues | Metabolic syndromes, acromegaly, hyper- prolactinemia etc.* | Oral | Protein |
Preclinical | The technology and "know-how" to synthesize somatostatin analogues which will be more potent, more specific, stable and orally available have been established. A few analogues (at lead generation/optimization stage) with different combination of receptor selectivity and differential hormonal secretion inhibition properties are available. *: Congenital hyperinsulinism, insulinomas, glucagonomas |
問合せ |
| 19/04/02 | GEM071 | Nanoparticl formulation of 2-deoxy-glucose | Hepatocellular carcinoma, Renal cancer, Colorectal canser | i.v. | Small molecule |
Preclinical | In the xenograft model, the administration of nanoparticle formulation once a week showed superior antitumor effect than daily administration of 2-deoxyglucose alone. No side effects were observed. Enhanced the antitumor effect by combination with existing anticancer drugs. Enhanced T cell infiltration into tumor tissue. The substrate used in the nanoparticle formulation are used in approved medicines (FDA). |
問合せ |
| 19/04/02 | GEM070 | Nanoparticl formulation of ɤ- Oryzanol | Diabetes, hyperlipidemia, menopausal disorder, irritable bowel syndrome, etc. | Oral | Small molecule |
Preclinical | Improved intestinal absorption and shows a drug effect in an extremely small amount (1/1000 of normal particles). Reduced preference for high fat diet. Suppressed ER stress enhancement on hypothalamic/pancreatic islet. Improved abnormal glucose metabolism and abnormal lipid metabolism. The substrate used in the nanoparticle formulation are used in approved medicines (FDA). |
問合せ |
| 19/03/12 | GEM024 | 1. Selective inducer of apoptosis through modulation of NF-kB/P53 axis. / 2. Eliciting adaptive immune response by recruitment of T Cells to tumors. | Oral Squamous Cell Carcinoma | see Note | Small molecule |
Phase 2 ready | Updated on March 12, 2019 First-in-class, patented, combination therapeutic that simultaneously upregulates a cluster of genes promoting cell death and downregulates a cluster of genes promoting survival of cancer cells. Phase 1 results showed no significant AE, dose-dependent modulation of key biomarkers involved in disease pathogenesis, and T cell recruitment to tumor making it “hot”. FDA approved moving to Phase 2. Route:Oral, pastille based topical delivery |
問合せ |
| 19/03/07 | GEM069 | Immuno-modulator (adjuvant) | Vaccine, Please refer to Note | Injection | Other |
Preclinical | E.coli producing monophosphoryl Lipid A whose structure is similar to exsiting adjuvants such as MPL and GLA. Shows similar efficacy with MPL in vitro and in vivo. Lower cost production through simple fermetation and purification steps. Indication:Vaccine, Cancer immunotherapy etc. |
問合せ |
| 19/03/01 | GEM068 | Gene therapy for novel target | Lung and other cancers | i.v. | Nucleic acid |
Preclinical | The expression of this gene is reduced in various cancers. Adenovirus expressing this gene inhibits the HIF-1α expression and proliferation of various cancer cells. Adenovirus expressing this gene suppresses growth of lung cancer in nude mice. |
問合せ |
| 19/03/01 | GEM067 | c-Kit inhibitor | Diabetic macular edema & Retinopathy | Oral | Small molecule |
Phase 2a | Inhibits stem cell factor-induced hyperpermeability Reverses retinal vascular leakage in STZ-induced diabetic rats Improved compliance to administration (oral) than anti-VEGF therapy (intra-vitreal injection) Applicable to non-responders to anti-VEGF therapy Repositioning of a marketed drug |
問合せ |
| 19/03/01 | GEM066 | Selective STAT3 inhibitor (DNA-based Decoy) | Head and neck squamous cell carcinoma and non-small cell lung cancer [including exon 20 mutations] | i.v. | Nucleic acid |
Pre-IND for systemic administration formulation | 1st-in-class STAT3 decoy; Suppresses binding of STAT3 to genomic DNA; Inhibits proliferation and promotes apoptosis of many cancer cells; Suppresses expression of STAT3 target genes and tumor growth in animal models; Shows increased response in combination with cetuximab and also with PD-1; Human Phase 0 study (intratumor injection); Suppresses STAT3 target genes expression with one dose Does not affect normal oral keratinocytes; Exploratory animal toxicology studies show no significant adverse effects; |
問合せ |
| 19/03/01 | GEM064 | Selective inhibitor of Nav channels | Pain | Oral | Small molecule |
Preclinical | Potent and selective inhibitors for Nav 1.7/1.8 subtypes Effective in inflammatory & neuropathic pain states Exellent non-clinical ADMET profile No off-target activity, very good in vitro cardiac safety margin, non-mutagenic |
問合せ |