創薬流通市場「薬市楽座」

安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。

創薬流通市場である薬市楽座では、弊社がお預かりしている創薬シーズ・技術の情報をリストアップしています。ご興味に応じて検索していただくことが可能です。また、リストのダウンロードも行っていただけます。ご興味のあるものがあれば、お問い合わせボタンをクリックしていただき、弊社へのコンタクトをお願いいたします。追加情報を開示させていただきます。

なお、2019年6月27日より、日本語ページにおける、創薬シーズ、創薬技術の各リスト表記が英語に変更になりました。ダウンロード用のPDF、エクセルファイルは英語ページよりダウンロードできる資料と同一ですので、予めご了承下さいませ。

創薬シーズ・創薬技術一覧(PDF) 疾患領域別 創薬シーズ一覧(PDF) 創薬シーズ・創薬技術一覧(Excel)

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掲載日 シーズ番号 作用機序 適応症 投与経路 モダリティ 開発ステージ 備考
19/12/24 GEM137 Biosimilar ranibizumab Same indications as ranibizumab intra- vetreal Antibody Preclinical Peptide mapping by Mass Spectrometry confirms amino acid sequence identity of GEM137 with ranibizumab. Purified GEM137 is highly similar to ranibizumab by SDS-PAGE. Ligand (rVEGF) biding by GEM137 demonstrated to be similar to ranibizumab by ELISA. Plant-based technology (TGEM036) was applied for production of GEM137. 問合せ
19/12/24 GEM136 Biosimilar trastuzumab Same indications as trastuzumab i.v. Antibody Preclinical GEM136 N-terminal sequences are identical to trastuzumab. Levels of contaminating proteins, profiles of breakdown products and inhibitory activity to trastuzumab on in vitro growth of hER2 positive breast cancer cell line are similar between GEM136 and trastuzumab. Plant-based technology (TGEM036) was applied for production of GEM136. 問合せ
19/12/20 GEM135 Inhibition of proteasome via novel target Multiple tumors i.v., i.p. and Oral Small molecule Preclinical Novel target different from that for all the commercially available proteasome inhibitors. Works against many cancer cell lines tested including bortezomib, cisplatin and paclitaxel resistant cell lines. Significant therapeutic window between cancer and normal cells. Favorable toxicity profile. Regressed tumor growth and prolonged survival on syngeneic and xenograft mouse models. Expected to be effective against solid tumors without off target effects and peripheral neuropathy. Two lead compounds are being developed. 問合せ
19/12/06 GEM134 Anti-CD147 antibody Hematological (AML,MM etc) and solid tumors(liver, colon, lung etc) i.v. Antibody Preclinical Fully human antibody binding to human/ cynomolgus CD147.
Has been shown to be very effective in various types of cancers in vivo xenograft mouse model.
ADCC activity mainly contributes to the anti-tumor effect.
問合せ
19/11/29 GEM058 Increase cellular ATP and promote wound healing Diabetes foot ulcer Topical Small molecules Phase 2 completed Reducing inflammation of endothelial cells of blood vessels.
Increasing cellular ATP and speeding up the healing of wounds by promoting the migration of epithelia cells in the skin of wounds. The arrangement of actin which is essential for cell migration is ATP dependent.
Applicable to all kind of wound and low cost treatment
問合せ
19/11/25 GEM133 Myocardial protection by cardiac arrest temporally Open heart surgery Intra- coronary infusion Others
Launched GEM133 is a novel warm cardioplegic solution which in mixture with patient's oxygenated blood can produce effective and sustained cardiac arrest by a single dose 400ml. In addition, it has the following advantages; virtually unlimited aortic cross-clamp time, unassisted resumption of the cardiac rhythm, no ischemic and /or reperfusion injury, no need for cardiotonic support in the immediate postopertaive period. 問合せ
19/11/15 GEM132 Matrix metalloproteinase-13 (MMP-13) inhibitor Refer to Note Intra- articular or Oral Small molecule
Preclinical Indication:
Osteoarthritis (OA)

Note:
Extremely potent non-hydroxamic acid containing, non-zinc binding inhibitors of MMP-13 have been identified. High selectivity has been shown for this class of inhibitors over other MMPs. Lead inhibitor tested in the monoiodoacetate (MIA) rat model of OA and shown to protect cartilage when injected into the joint. Exhibits good oral bioavailability in the rat.
問合せ
19/11/15 GEM131 Matrix metalloproteinase-2 (MMP-2) and MMP-9 inhibitor Refer to Note Oral Small molecule
Close to IND ready * Indication:
Neuropathic pain and Amyotrophic Lateral Sclerosis (ALS)

Note:
Pain: GEM131 can block inflammatory responses at the site of nerve damage and has been shown to be efficacious in 4 different rodent models of neuropathic pain (spinal nerve ligation, chronic constriction injury of the infraorbital nerve, morphine withdrawal and thermal injury).
ALS: Elevated levels of MMP-2 and-9 have been found in the skin and blood of people with ALS. Significantly improved larval locomotion in both the TDP-43 and SOD1 larvae models in Drosophila. Exhibits good oral bioavailability.
*: Final stages of completion of IND enabling studies for both neuropathic pain & ALS
問合せ
19/11/15 GEM130 Antiviral Infections caused by herpes simplex virus in face and lip Topical Small molecule
Launched · First cold sore product on the market that combines the therapeutic benefits of an antiviral with an innovative transparent bioadhesive film. · When applied to the lesion, generates a transparent film that acts as a bioadhesive sustained matrix release that improves product bioavailability while promotes itching reduction and wound healing.
· Indicated for the topical treatment of symptoms (tingling, burning, discomfort) of recurrent herpes labialis caused by herpes simplex virus (VHS).
問合せ
19/11/15 GEM129 Immuno-modulator Anogenital warts, Actinic keratosis, Basal cell carcinoma Topical Small molecule
Phase 2 · The first product on the market that combines the therapeutic benefits of a marketed immunomodulator with an innovative transparent bioadhesive film.
· When applied to the lesion, generates a transparent bioadhesive film, which acts as a reservoir or matrix release and reduces the local reactions and increases the permanence of the product in the action site. · The results of non-clinical studies demonstrate that GEM129 has a better safety profile with an equivalent efficacy than its reference product. Clinical studies on-going.
問合せ