創薬流通市場「薬市楽座」
安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。
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なお、2019年6月27日より、日本語ページにおける、創薬シーズ、創薬技術の各リスト表記が英語に変更になりました。ダウンロード用のPDF、エクセルファイルは英語ページよりダウンロードできる資料と同一ですので、予めご了承下さいませ。
| 掲載日 | シーズ番号 | 作用機序 | 適応症 | 投与経路 | モダリティ | 開発ステージ | 備考 | |
|---|---|---|---|---|---|---|---|---|
| 19/06/27 | GEM082 | Modified IL-1 receptor antagonist (IL-1RA) | Refer to Note | Intra-articular | Protein |
Preclinical | Indication: Osteoarthritis, gout, anterior cruciate ligament (ACL) injury Single intra-articular injection of Anakinra (rhIL-1RA) improved OA symptoms vs placebo in clinical Phase-2 but the effect was short-lasting. GEM082 showed prolonged retention in the joint and sustained efficacy. GEM082 targets directly the biology of the inflammasome, involved in acute OA pain flares, without the adverse effects of steroids. Avaliable for licensing to Japan, China and Taiwan. |
問合せ |
| 19/06/12 | GEM081 | Oncolytic virus | Refer to Note | IM | Virus |
Phase 2 ready | Indication: Solid tumor (Melanoma, GI cancer etc.) Genetically non-modified and non-pathogenic virus with - oncolytic, oncotropic and immunomodulating properties - excellent safety profile - various development options Medicine containing this virus is already approved for treatment for many years in certain countries. This virus has established fully GMP certified API production |
問合せ |
| 19/06/06 | GEM080 | Novel cell surface receptor for insoluble protein involved in Parkinson's/Lewy body diseases | Parkinson's diseases, Lewy body disease | NA | NA |
Preclinical | Cell surface receptors for insoluble protein involved in Parkinson's disease/Lewy body disease which were newly identified by utilizing artificial liposomes embedded with endogenous membrane proteins (see TGEM025 in Technology). Antagonists of the receptors are expected to be effective on Parkinson's/Lewy body diseases. | 問合せ |
| 19/06/06 | GEM079 | Novel cell surface receptor for angiogenesis regulation | Cancers, chronic inflammation, diabetic retinopathy , myocardial infarction, etc | NA | NA |
Preclinical | Cell surface receptor involved in angiogenesis which was newly identified by utilizing artificial liposomes embedded with endogenous membrane proteins (see TGEM025 in Technology). Agonists of the receptor are expected to be effective on diseases where angiogenesis is involved as an aggravating factor. | 問合せ |
| 19/05/30 | GEM078 | Hyaluronic acid-based nanocarriers of cisplatin | Head and neck cancer, pancreatic cancer, melanoma with metastasis | IV | Small molecule |
Preclinical | CD44 targeting and higher stability lead to enhance lymphatic delivery and inhibit cancer with lymphatic metastasis. Chemodrug encapsulated by nanocarriers minimize systemic toxicities. Convenient dosing by intravenous injection. |
問合せ |
| 19/05/30 | GEM077 | AMPK activator | Topical fat accumulation | Transdermal or oral | Small molecule |
Preclinical | A small molecular AMPK activator. It inhibited the growth of adipocytes in vitro and suppressed body weight and fat increases in vivo. Topical used formulation is under testing. | 問合せ |
| 19/05/30 | GEM076 | Galectin-12 inhibitor | Seborrheic dermatitis; Sebaceous hyperplasia | Transdermal | siRNA |
Preclinical | A modified siRNA for suppressing gene expression of galectin-12 which is a lipid droplet protein and regulates lipid accumulation and lipolysis. The siRNA can reduce the lipid in sebocytes and adipocytes and shows good stability and selectivity to reduce the lipid accumulation through transdermal delivery in vivo. | 問合せ |
| 19/05/30 | GEM075 | Novel functional excipient | Oral formulation* | Oral | Polymer |
Preclinical | The synthetic polyvinyl acetate (PVAc)-based polymer of functional excipient is utilized as solubilizer that could increase drug solubility and enhance drug absorption. This novel excipient has better flowability, easy for use and widely application. This excipient will be useful for new drug and insoluble drug development. *: e.g. direct compression, granulation, solid dispersion |
問合せ |
| 19/05/30 | GEM074 | Dual inhibitor of Topo 1 and Topo 2 | Drug resistant cancers | IV | Small molecule |
Phase I | 1st-in-class combo therapy, covalently conjugated to simultaneously inhibit Topo 1 and 2, w/ EGFR cross-talk and extremely low toxicity for high dosing. Reduced tumor sizes w/ 38% CR and 98% TGI (compared to 0% and 33%, respectively, for imatinib) in CML xenograft models; and 98% TGI in colon cancer models at low doses. Showed immunotherapy enhancement effects with anti-PD-1 Ab and anti-CTLA-4 Ab with 100% CR in ovarian cancer model. No toxicity in rat & monkey models; No SAEs reported in Phase I at high dose 180mg/m2. Excellent PK profile and GI permeability of 9.2 enabling oral formulation. |
問合せ |
| 19/05/30 | GEM073 | Kinase inhibitor of TGFβ-mediated phospho-SMAD2 signal transduction | COPD, IPF, Lung cancer | Oral | Small molecule |
Phase I ongoing | This kinase is selectively expressed in resident macrophages and airways epithelia of the lung and upregulated in COPD and IPF patients. A highly selective inhibitor showed efficacy across at least 3 different animal models relevant to COPD, IPF and NSCLC. |
問合せ |