創薬流通市場「薬市楽座」
安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。
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| 掲載日 | シーズ番号 | 作用機序 | 適応症 | 投与経路 | モダリティ | 開発ステージ | 備考 | |
|---|---|---|---|---|---|---|---|---|
| 19/10/29 | GEM123 | miRNA targeting cancer stem cells | colon cancer | i.v. | Nucleic acid |
Preclinical | GEM123 suppressed the stemness of cancer cells by inhibiting KLF5 expression, and provoked apoptosis and cycle arrest through the downregulation of TFDP1and MDM2 expressions. GEM123 also inhibited tumor growth with no apparent side effect in mouse model. |
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| 19/10/29 | GEM122 | Natural Killer T (NKT) cell-mediated anti-tumor responses | Solid cancer | i.v. | Cell Therapy |
Phase 1 | GEM122 shows its anti-tumor activity by activating endogenous NKT cells. Activated NKT cells strongly enhance both innate and acquired immune systems, induce the long-term immune memory and promote accumulation of TILs (tumor infiltrating lymphocytes) in tumor sites. GEM122 consists of a novel NKT ligand and a novel APC. The novel NKT ligand shows much stronger NKT activity than the previous NKT ligand, α-Galactosylceramide and by using the novel APC, the cellular product can be manufactured efficiently as well. |
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| 19/10/23 | GEM121 | Modified phytic acid (inositol hexaphosphate: IP6) | Cancer | Oral | Small molecule |
Preclinical | · Demonstrated selective anti-cancer effects including apoptosis and inhibition of Akt activation. · In vivo study using mice with adult T-cell leukemia showed reduction of the size of the cancer. |
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| 19/10/23 | GEM120 | Inhibition of membrane binding of Pr55Gag | HIV | i.v. | Small molecule |
Preclinical | · Inhibited the membrane localization of Pr55Gag and stopped budding of HIV virus. · Captures HIV in immune cells and induces apoptosis of the HIV-infected immune cells. |
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| 19/10/23 | GEM119 | Inactivation of end-product of lipid peroxidation | Cerebral Infarction | i.v. | Small molecule |
Preclinical | · Showed more potent 4-hydroxynonenal - quenching activity compared with carnosine or histidine hydrazide (HH) at 30min incubation. · GEM119 ( ip administration) rescued the hippocampal CA1 cell death of transient cerebral ischemia model of Mongolian gerbil whereas HH did not. |
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| 19/10/23 | GEM118 | Suppression of TGF-b/Smad and related signaling | Systemic sclerosis | Oral | Small molecule |
Preclinical | · Inhibited phosphorylation of Smad3 and expression of Col1a2, FN1 and CTGF stimulated by TGF-b in cultured human dermal fibroblasts. · Ameliorated bleomycin-induced skin fibrosis in both preventative and curative mouse model. |
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| 19/10/16 | GEM117 | Induction of apoptosis in adipocyte | Lipolysis, non-surgical fat reduction, Diabetes | Refer to Note | Small molecule |
Phase 2a | Route: Subcutaneous Note: · GEM117 specifically induce apoptosis on local injection site adipocyte · Phase 1 showed great safety without drug related SAE in 40 healthy volunteers · In pre-clinical study - Better efficacy on local fat reduction and less side effects that surpass the current surgical liposuction and other non-surgical products. - Has benefit effects on lipid and glucose metabolism and improves the indicator of diabetes |
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| 19/10/16 | GEM116 | Increase in lipolysis, fat and energy metabolism | Obesity, Diabetes, NAFLD/NASH | Oral | Small molecule |
Phase 2 | ·GEM116 demonstrated the safest profile in its clinical phase 2 study with more than 200 patients without any drug related AE or SAE and potentially lower CVD risk seen by other competitors in the market · Around 30% of subjects lost at least 5% body weight in 12 weeks, GEM116 shows around 5% body fat lost, lower TC by around 12mg/dL, and lower LDL by around 6 mg/dL ·Pre-clinical study shows GEM116 has the potential to treat NAFLD/NASH via reducing liver fibrosis by aroud 40% . |
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| 19/10/16 | GEM115 | Trastuzumab biosimilar-ADC | HER2-positive metastatic breast cancer | i.v. | Antibody |
Phase 1 | Conjugate of trastuzumab biosimilar and DM-1. The profiles of trastuzumab of GEM115 and GEM115 are similar to Herceptin and Kadcyla, respectively, in peptide mapping, receptor binding affinity, inhibition of cell proliferation, ADCC activities, in vivo xenograft mouse model, PK etc. Potential Indication: Early Breast Cancer (adjuvant) |
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| 19/10/16 | GEM114 | Ophthalmic formulation of GEM113 | wet AMD | intra vitreal | Antibody |
Phase 1 | GEM114 mainly distributed in retina, vitreous body and aqueous humor after intravetreal injection in animals. Potential Indication: Diabetic Macular Edema; Myopic Choroidal Neovascularization (mCNV); Retinal Vein Occlusion (RVO); Diabetic Retinopathy (DR) |
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