創薬流通市場「薬市楽座」
安土桃山時代に自由取引市場として発展した「楽市楽座」にあやかり、創薬シーズ・技術のマーケットプラットフォームを創薬流通市場、「薬市楽座」と名付けました。このマーケットが楽市楽座のように発展することを願っています。
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なお、2019年6月27日より、日本語ページにおける、創薬シーズ、創薬技術の各リスト表記が英語に変更になりました。ダウンロード用のPDF、エクセルファイルは英語ページよりダウンロードできる資料と同一ですので、予めご了承下さいませ。
| 掲載日 | シーズ番号 | 作用機序 | 適応症 | 投与経路 | モダリティ | 開発ステージ | 備考 | |
|---|---|---|---|---|---|---|---|---|
| 20/08/24 | GEM192 | Selective PI3Kα inhibitor | Slow-flow vascular malformations | Oral | Small molecule | Phase 1 | Slow-flow vascular malformations including venous malformation, lymphatic malformation, Klippel-Trenaunay syndrome is abnormal clustering of blood vessels that occurs in children or young adults and are caused by PI3K pathway GOF mutation. By selectively inhibiting PI3Kα isoform, GEM192 inhibits angiogenesis, but not immune function resulting in better therapeutic effects and lower infectious risk. Phase 1/2 data for another indication demonstrate a favorable tolerability profile. Clinical development to be pursued with new pediatric formulation. | 問合せ |
| 20/08/24 | GEM185 | GLP-1/GIP dual agonist | Obesity, diabetes | s.c. | Peptide | Phase 1 | GEM185 is an injectable (QD) dual agonist for GLP-1R and GIPR. Preclinical studies have shown that GEM185 is more effective in improving diabetes and obesity than GLP-1R agonism only. In addition, GEM185 has been shown to improve liver parameters in diabetic and obesity conditions in preclinical research. Hence, GEM185 may be superior to the GLP-1R agonist in improving diabetes, obesity, and non-alcoholic steatohepatitis (NASH). In a preclinical study, GEM185 showed better efficacy in improving glycemic control and an almost same efficacy in decreasing body weight compared to tirzepatide, a Lilly’s Ph3 program. A long-acting formulation, which is likely to maximize its therapeutic efficacy, are under development. A phase 1 study (first-in-human study), starting in 2020, is being organized in the UK. | 問合せ |
| 20/08/12 | GEM204 | Multi-molecular targeting including the Wnt/𝛽-catenin pathway | Hair loss, Andogenetic alopecia, Telogen effluvium, Senescent alopecia | Topical and/or oral | Plant extracts | Commercial | GEM204 is a comprehensive solution for the treatment of hair loss, targeting more than 21 hair regulating molecular pathways to promote hair growth and inhibit hair loss. Market approval and full scientific dossier available with clinical trials in women and men of all hair loss patterns, hair types and skin types. | 問合せ |
| 20/08/10 | GEM203 | FXR agonist and 5-HTR2A antagonist | NAFLD, Type 2 diabetes, obesity, dyslipidemia and hypertension | Oral | Small molecule | Preclinical | First in class single molecule having both FXR agonistic and 5-HTR2A antagonistic actions. In DIO mice, GEM203 reduced hyperglycemia, hyperinsulinemia, insulin resistance and liver lipid contents to similar or greater extent vs metformin. GEM203 reduced the body excess weight while metformin did not. In NASH model mice, GEM203 reduced liver excess weight, TG and TC contents, plasma ALT and AST, inflammation and collagen gene expression in the liver. Strong IP portfolio with long expiry dates granted in major markets. |
問合せ |
| 20/08/05 | GEM202 | Somatostatin receptor subtype 5 (SSTR5) antagonist | Type 2 diabetes, Gallstone, Primary sclerosing cholangitis （PSC）, Inflammatory bowel disease （IBD）, short bowel syndrome （SBS） | Oral | Small molecule | IND ready | SSTR5 is primarily expressed in pancreatic ß-cells and enteroendocrine cells, and its ligand, somatostatin, negatively regulates the secretion of insulin and gut hormones (GLP-1, GLP-2, PYY, etc.). GEM202 is a selective SSTR5 antagonist and is unique owing to its dual action of elevating these hormone secretions and increasing insulin sensitivity, thereby improves glycemic control in obese and diabetic mice. In addition, GEM202 is effective in stimulating gallbladder motility and increasing bile flow, accounting for its therapeutic effects in animal models of gallstones and PSC. Thus, an additional potential application involves treatment of hepatobiliary diseases. Patents have been filed globally. | 問合せ |
| 20/08/01 | GEM201 | mRNA Vaccine Platform technology. Production of S-Protient with Immune-modulators in one construct | Coronavirus （COVID-19）; Broader Vaccine Platform | i.v. | Drug Delivery, Cell therapy | Preclinical | GEM201 utilizes TGEM055 technology loaded with antigenetic proteins as a mRNA Vaccine Platform - Produce functional antigenetic protiens in Lymphatic organs - Localized antigen induction at high intracellular amounts where antigen presenting cells aggregate. Co-delivery of potent Immune-modulators (GM-CSF, IL-12, etc) sumultaneously - GEM201 is a vaccine platform - GEM201 is critical for vaccination of elderly and immune suppresed populati |
問合せ |
| 20/07/22 | GEM200 | Physically damage bacterial membranes | Multidrug-resistant bacteria | i.v. | Peptide | Preclinical | A bioengineered peptide that is effective against Gram(-) bacteria and works regardless of any underlying resistance the bacteria may have against other antibiotic drugs. GEM200 is highly efficient against Multi Drug Resistant Acinetobacter baumannii in hospital acquired infections and its unique MoA lowers the probability for development of future resistance or tolerance. GEM200 is Effective where the Standard of Care drugs fail. Advantages: - High effecacy in systemic IV administration - Rapid bactericidal MOA that avoids resistance - Targets bacteria only – Non-toxic to human cells - Stable peptides with T1/2=~8 hours in human plasma |
問合せ |
| 20/07/08 | GEM199 | A fixed dose combination of Minoxidil, resveratrol and melatonin | Alopecia / Hair Loss | Topical | Small molecule | Pre registration | Minoxidil is a potassium channel blocker that prevents hair loss by improving blood flow to the hair follicle. It also suppresses androgen receptor function and stimulates the production of prostaglandins. Resveratrol stimulates hair growth by decreasing prostaglandin D2 (PGD2) and increasing prostaglandin E2 (PGE2). Melatonin is a neurohormone involved in multiple physiological processes underlying circadian rhythm. Due to its antioxidant properties, melatonin has remarkable protective effects on cells and anti-apoptotic properties. Hence the association between melatonin and hair growth. The effect of melatonin on hair growth may be moderated by an interaction with androgens and estrogens and their receptors. Results from a clinical study demonstrated that GEM199 was more effective at stopping hair loss than Minoxidil. US patent issued, and international patents have been filed. | 問合せ |
| 20/07/08 | GEM198 | A fixed dose combination of melatonin and resveratrol | Alopecia / Hair Loss | Topical | Small molecule | Pre registration | Resveratrol stimulates hair growth by decreasing prostaglandin D2 (PGD2) and increasing prostaglandin E2 (PGE2). Melatonin is a neurohormone involved in multiple physiological processes underlying circadian rhythm. Due to its antioxidant properties, melatonin has remarkable protective effects on cells and anti-apoptotic properties. Hence the association between melatonin and hair growth. The effect of melatonin on hair growth may be moderated by an interaction with androgens and estrogens and their receptors. Results from a clinical study demonstrated that GEM198 was more effective at stopping hair loss than Minoxidil. US patent issued, and international patents have been filed. | 問合せ |
| 20/07/08 | GEM197 | A fixed dose combination of minoxidil, finasteride and latanoprost | Androgenetic alopecia | Topical | Small molecule | Phase 3 | Minoxidil is a potassium channel blocker that prevents hair loss by improving blood flow to the hair follicle. It also suppresses androgen receptor function and stimulates the production of prostaglandins. Finasteride is a 5 alpha reductase inhibitor that reduces the conversion of testosterone to dihydrotestosterone (DHT), which in turn reduces the binding of DHT to the androgen receptor, thereby reducing the miniaturization of the hair follicle. Finasteride also upregulates SULT1A1, which activates the pro-drug of minoxidil into its active form - minoxidil sulfate Latanoprost is a prostaglandin analogue that has a positive stimulatory effect on the hair follicle and induces the conversion from telogen to anagen phase in the hair growth cycle. Results from a completed phase 2 study have demonstrated that GEM197 is a well-tolerated, once a day, topical fixed dose triple combination therapy that stimulates new hair growth and prevents further hair loss for the treatment of androgenetic alopecia in men 24-65 years old. The FDA has given a roadmap to start a Phase 3 clinical trial under 505(b)(2). International patents have been issued. | 問合せ |